Condition: Parkinson Disease · Sponsor: Appello Pharmaceuticals, Inc.
This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa treatment, compared with a placebo. The study will last about 12 weeks. Participants will be randomly assigned to receive one of the two doses of AP-472 or a placebo. Neither the participants nor the study staff will know which treatment is given. The study includes a screening period, a 4-week period during which Parkinson's medications must remain stable, and an 8-week treatment period. During the treatment period, limited adjustments to levodopa are allowed if needed.
This description comes directly from the study's public registry record.
Annie Blobaum, Ph.D. · 615-427-1935 · annie@appellopharma.com
Always discuss trial participation with your own doctor first.
| University of Arkansas for Medical Sciences (Site #208) | Little Rock, Arkansas, United States | Not Yet Recruiting |
| Profound Research LLC (Site #222) | Carlsbad, California, United States | Recruiting |
| Collaborative Neuroscience Network - Los Alamitos- CenExel - PPDS (Site #217) | Los Alamitos, California, United States | Recruiting |
| Keck Medicine of USC - USC Healthcare Center 2 (Site #221) | Los Angeles, California, United States | Not Yet Recruiting |
| Parkinson's Research Centers of America (Site #218) | Palo Alto, California, United States | Recruiting |
| Rocky Mountain Clinical Research - CenExel - PPDS (Site #215) | Englewood, Colorado, United States | Recruiting |
| Parkinson's Disease & Movement Disorders Center of Boca Raton (Site #227) | Boca Raton, Florida, United States | Recruiting |
| UM-UHealth at Boca Raton (Site #226) | Boca Raton, Florida, United States | Not Yet Recruiting |
| Velocity Clinical Research - Hallandale Beach (Site #228) | Hallandale, Florida, United States | Recruiting |
| University of Miami (Site #220) | Miami, Florida, United States | Not Yet Recruiting |
| Neurology One (Site #205) | Orlando, Florida, United States | Recruiting |
| USF Parkinson's Disease and Movement Disorders Center (Site #206) | Tampa, Florida, United States | Not Yet Recruiting |
+ 18 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07432958