Condition: Frailty · Cognitive Impairment · Older Adults · Sponsor: Tomas Bata Hospital, Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented. The study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications. Approximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preop…
This description comes directly from the study's public registry record.
Klára Nekvindová, M.D, Ph.D. · +420577 551 111 · nekvindova.klara@gmail.com
Always discuss trial participation with your own doctor first.
| University Hospital Brno - Bohunice | Brno, Czechia | Not Yet Recruiting |
| University Hospital Olomouc - Department of Anaesthesiology, Resuscitation and Intensive Care | Olomouc, Czechia | Not Yet Recruiting |
| University Hospital Ostrava - Department of Anaesthesiology, Resuscitation and Intensive Care | Ostrava, Czechia | Not Yet Recruiting |
| University Hospital Královské Vinohrady | Prague, Czechia | Not Yet Recruiting |
| University Hospital Motol | Prague, Czechia | Not Yet Recruiting |
| Vsetín Hospital | Vsetín, Czechia | Not Yet Recruiting |
| Tomas Bata Regional Hospital | Zlín, Czechia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07432009