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Study identifier: NCT07431281 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

Condition: Gastric Cancer · Gastroesophageal Junction Adenocarcinoma · Esophageal Cancer  ·  Sponsor: AstraZeneca

PhasePhase 3
Planned participants2130
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy and safety of sonesitatug vedotin in combination with capecitabine with or without rilvegostomig in first-line (1L) Claudin18.2 (CLDN18.2)-positive, human epidermal growth factor receptor 2 (HER2)-negative, gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (286)

Research SiteMobile, Alabama, United StatesNot Yet Recruiting
Research SiteAnchorage, Alaska, United StatesNot Yet Recruiting
Research SitePhoenix, Arizona, United StatesNot Yet Recruiting
Research SiteSpringdale, Arkansas, United StatesNot Yet Recruiting
Research SiteDuarte, California, United StatesNot Yet Recruiting
Research SiteFullerton, California, United StatesNot Yet Recruiting
Research SiteLa Jolla, California, United StatesNot Yet Recruiting
Research SiteLos Alamitos, California, United StatesNot Yet Recruiting
Research SiteOrange, California, United StatesNot Yet Recruiting
Research SiteWalnut Creek, California, United StatesNot Yet Recruiting
Research SiteDenver, Colorado, United StatesNot Yet Recruiting
Research SiteLone Tree, Colorado, United StatesNot Yet Recruiting

+ 274 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07431281