Condition: Pulmonary Embolism (Diagnosis) · Sponsor: Karolinska Institutet
Pulmonary embolism (PE) is a serious condition caused by blood clots blocking the blood vessels in the lungs. In some patients, PE leads to increased pressure in the lung circulation and strain on the right side of the heart. Patients with intermediate high-risk PE have signs of right heart stress and heart muscle injury and are at risk of clinical deterioration despite standard treatment with anticoagulation. In addition to the mechanical obstruction caused by blood clots, pulmonary embolism also causes narrowing of the lung blood vessels due to vasoconstriction. This increases pulmonary vascular resistance and contributes to elevated pressure in the pulmonary arteries, which can worsen right heart function. Treatments that reduce pulmonary artery pressure and vascular resistance could therefore potentially improve heart function and stabilize patients in the acute phase of PE. However, there is limited clinical evidence regarding the safety and effectiveness of pulmonary vasodilator therapy in this patient group. Inorganic nitrates, found naturally in foods such as beetroot, are converted in the body to nitric oxide, a substance that relaxes blood vessels. Inorganic nitrates have been shown to lower blood pressure and improve pulmonary hemodynamics in other cardiovascular conditions, and are generally considered safe. Their effects in patients with intermediate high-risk pulmonary embolism have not previously been studied in a randomized controlled trial. The aim of this…
This description comes directly from the study's public registry record.
Jacob M Hollenberg, Professor · (+46) 070-4133442 · jacob.hollenberg@ki.se
Olle M Andersson, PhD · (+46) 072-9174349 · olle.andersson@ki.se
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| South hospital Stockholm | Stockholm, Sweden | Recruiting |
| Stockholm, Sweden | Stockholm, Sweden | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07431229