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Study identifier: NCT07431125 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Surgical-Clinical Correlation in Unilateral Conductive Hearing Loss With Intact Tympanic Membrane

Condition: Conductive Hearing Loss, Unilateral  ·  Sponsor: Al-Azhar University

PhaseNA
Planned participants100
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

Unilateral conductive hearing loss (UCHL) in the presence of an intact tympanic membrane represents a diagnostic challenge in otologic practice. In the absence of middle ear effusion or tympanic membrane pathology, stapes fixation secondary to otosclerosis is often considered the most probable diagnosis. However, although otosclerosis is traditionally regarded as a bilateral disease, clinical presentation may be unilateral due to asymmetric disease progression or subclinical contralateral involvement. Other etiologies, including congenital ossicular anomalies, ossicular discontinuity, tympanosclerosis without tympanic membrane involvement, or oval window abnormalities, may mimic otosclerosis both clinically and audiologically. Consequently, exploratory tympanotomy remains the gold standard for definitive diagnosis, allowing direct assessment of ossicular chain mobility and confirmation of stapes fixation. Correlating preoperative clinical suspicion with intraoperative findings is therefore essential to better define the true causes of unilateral conductive hearing loss with an intact tympanic membrane.

This description comes directly from the study's public registry record.

Talk to the study team

tarek Mansour, head of research committe  ·  +0201006237731  ·  ethicscommitt0ee@azhar.edu.eg

Always discuss trial participation with your own doctor first.

Locations (1)

Alazhar university Hopital in AssiutAsyut, Asyut Governorate, EgyptRecruiting

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Source record: clinicaltrials.gov/study/NCT07431125