Condition: Atrial Fibrillation (AF) · Sponsor: Regeneron Pharmaceuticals
This study is researching 2 different experimental drugs called REGN7508 and REGN9933 (called "study drugs"). The study is focused on people who have atrial fibrillation, which means that the heart beats too fast and unevenly. When this happens, blood cannot move smoothly through the heart; it can slow down or pool in one spot, which can lead to the formation of blood clots. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how effective and safe REGN7508 and REGN9933, individually, are in preventing ischemic stroke or systemic embolism in people with atrial fibrillation who cannot or may choose to not take blood thinners. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well does REGN7508 or REGN9933 lower the risk of having an ischemic stroke and/or systemic embolism compared to the placebo * How well does REGN7508 or REGN9933 lower the risk of having a major health problem affecting heart and blood circulation compared to placebo * How well does REGN7508 or REGN9933 lower the risk of death compared to placebo * How much REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the study drugs less effective or could lead to side effects)
This description comes directly from the study's public registry record.
Clinical Trials Administrator · 844-734-6643 · clinicaltrials@regeneron.com
Always discuss trial participation with your own doctor first.
| SEC Clinical Research | Dothan, Alabama, United States | Recruiting |
| Mission Cardiovascular Research Institute | Fremont, California, United States | Recruiting |
| National Institute of California Heart and Vein Specialists | Huntington Beach, California, United States | Recruiting |
| Profound Research LLC at Southern California Heart Specialists | Pasadena, California, United States | Recruiting |
| Cardiology Associates Medical Group | Ventura, California, United States | Recruiting |
| Interventional Cardiology Medical Group | West Hills, California, United States | Recruiting |
| South Florida Research Organization LLC | Medley, Florida, United States | Recruiting |
| Sec Clinical Research | Pensacola, Florida, United States | Recruiting |
| Clinical Site Partners, LLC DBA Flourish Research | Winter Park, Florida, United States | Recruiting |
| NSC Research, Inc | Johns Creek, Georgia, United States | Recruiting |
| Monroe Research, LLC | West Monroe, Louisiana, United States | Recruiting |
| Profound Research, Millennium Cardiology | Farmington Hills, Michigan, United States | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07430956