Condition: HBV · HBV Coinfection · HCV · Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
HDV is an RNA virus that infects only in the presence of HBV, affecting about 13% of HBsAg carriers. In Italy, prevalence ranges from 3.2% to 9.3%. It increases the risk of cirrhosis, fulminant hepatitis, and HCC, particularly in high-risk groups (HIV, HCV, drug users, dialysis patients). Until 2020, pegIFN was the only therapy; since 2022, bulevirtide (BLV) has been available, blocking viral entry into hepatocytes and reducing HDV RNA and liver stiffness, with efficacy in 45-48% of patients, though the optimal treatment duration remains uncertain. The gut microbiota and bile acids also play a role in fibrosis and cirrhosis progression: dysbiosis, typical in cirrhotic patients, alters bile acid metabolism and increases intrahepatic toxicity.
This description comes directly from the study's public registry record.
Francesca Romana Ponziani · +390630159336 · francescaromana.ponziani@policlinicogemelli.it
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| Fondazione Policlinico Universitaro A. Gemelli IRCSS UOC CEMAD | Roma, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07429864