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Study identifier: NCT07428538 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

Condition: Hepatitis  ·  Sponsor: Bausch Health Americas, Inc.

PhasePhase 3
Planned participants350
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary purpose of this study is to evaluate the safety and efficacy of larsucosterol, as determined by transplant-free survival through Day 90 in participants with severe alcohol-associated hepatitis (AH) with pre-treatment Maddrey Discriminant Function (MDF) score greater than or equal to (\>=) 32 and Model for End-stage Liver Disease (MELD) scores 21-30, inclusive.

This description comes directly from the study's public registry record.

Talk to the study team

Varsha Bhatt  ·  707-230-1712  ·  varsha.bhatt@bauschhealth.com

Alycia Olsen  ·  201-846-8376  ·  Alycia.Olsen@bauschhealth.com

Always discuss trial participation with your own doctor first.

Locations (84)

University of Alabama at Birmingham (UAB) HospitalBirmingham, Alabama, United StatesRecruiting
University of South AlabamaMobile, Alabama, United StatesNot Yet Recruiting
Banner - University Medical Center, Phoenix, ArizonaPhoenix, Arizona, United StatesRecruiting
Mayo Clinic - PhoenixPhoenix, Arizona, United StatesNot Yet Recruiting
Southern California GI & Liver Centers - CoronadoCoronado, California, United StatesNot Yet Recruiting
ScrippsLa Jolla, California, United StatesNot Yet Recruiting
Cedars Sinai Medical CenterLos Angeles, California, United StatesNot Yet Recruiting
UCLA Health - Ronald Reagan Medical CenterLos Angeles, California, United StatesNot Yet Recruiting
Stanford Medicine - Clinical and Translational Research Unit - Redwood CityRedwood City, California, United StatesNot Yet Recruiting
University of California at Davis Medical CenterSacramento, California, United StatesNot Yet Recruiting
Sutter HealthSan Francisco, California, United StatesNot Yet Recruiting
Yale School of MedicineNew Haven, Connecticut, United StatesNot Yet Recruiting

+ 72 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07428538