Condition: Schizophrenia and Predominant Negative Symptoms · Sponsor: Douglas Mental Health University Institute
The goal of this clinical trial is to learn if an accelerated form of neuromodulation therapy can help improve negative symptoms of schizophrenia. Negative symptoms can include low motivation, reduced emotional expression, and difficulty with social interaction. The study will also look at how safe and tolerable this treatment is when given over a short period of time. Participants will be randomly assigned to receive either active neuromodulation therapy or sham (placebo) stimulation. The study will also compare two different ways of choosing where to place the stimulation. We want to learn whether this accelerated treatment approach is safe and feasible for people with schizophrenia, whether negative symptoms improve after treatment, and whether the way the stimulation site is chosen affects outcomes Participants will be asked to complete clinical interviews and questionnaires, undergo a brain scan, receive neuromodulation therapy or sham stimulation over five consecutive days, and attend follow-up visits after treatment This study is being conducted at three hospitals in Canada and is designed to help plan larger studies in the future.
This description comes directly from the study's public registry record.
Ashley S. Choucroun · ashley.choucroun.comtl@ssss.gouv.qc.ca
Always discuss trial participation with your own doctor first.
| Institut Universitaire en Santé Mentale de Montréal | Montreal, Quebec, Canada | Not Yet Recruiting |
| Institut universitaire de santé mentale de Québec - Centre de recherche CERVO | Québec, Quebec, Canada | Not Yet Recruiting |
| McGill Lab for Computational Psychiatry and Translation - Burland Pavilion 6875 Boulevard LaSalle Montreal, QC | Verdun, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07428460