Condition: Essential Tremor, Movement Disorders · Essential Tremor · Essential Tremor-plus · Sponsor: CND Life Sciences
Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to age-matched populations, with approximately 1% converting to PD annually. Post-mortem studies reveal Lewy body pathology in some ET patients, suggesting a subset may have prodromal PD. Current diagnostic tools (DaTscan, SYNTap) are either insufficiently sensitive for early disease, too expensive, or too invasive for routine screening. The Syn-One Test offers a minimally invasive approach to detect phosphorylated α-synuclein (P-SYN) pathology in skin biopsies. Primary Objectives 1. Identify which ET patients have P-SYN pathology indicative of prodromal PD 2. Predict which patients are most likely to phenoconvert to PD
This description comes directly from the study's public registry record.
Jeannie Director of Clinical Research · 480-434-6446 · ClinicalResearch@cndlifesciences.com
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| CND Clinical Research Center | Scottsdale, Arizona, United States | Recruiting |
| Veracity Neurosciences LLC | Memphis, Tennessee, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07428447