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Study identifier: NCT07428044 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

Condition: Non-Small Cell Lung Cancer · Non-small Cell Lung Cancer Stage II · Non-Small Cell Lung Cancer Stage IIIA  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants14
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out how many people with HER2-amplified or HER2-mutated non-small cell lung cancer (NSCLC) experience a decrease in tumor viability when they receive trastuzumab deruxtecan before routine surgery to remove tumors.

This description comes directly from the study's public registry record.

Talk to the study team

James Isbell, MD  ·  212-639-6247  ·  isbellj@mskcc.org

Jamie Chaft, MD  ·  646-608-3761  ·  chaftj@mskcc.org

Always discuss trial participation with your own doctor first.

Locations (10)

University of Michigan (Data Collection Only)Ann Arbor, Michigan, United StatesNot Yet Recruiting
Mayo Clinic (Data Collection Only)Rochester, Minnesota, United StatesNot Yet Recruiting
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activites)New York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activites)Rockville Centre, New York, United StatesRecruiting
Centre Hospitalier de l'Université de Montreal (Data Collection Only)Montreal, Quebec, CanadaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT07428044