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Study identifier: NCT07425457 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Condition: Arthroplasty · Replacement Material · Knee Arthritis Osteoarthritis  ·  Sponsor: Attikon Hospital

PhaseNA
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.

This description comes directly from the study's public registry record.

Talk to the study team

Dimitrios Filippiadis, MD, PhD, EBIR, MSc  ·  +306948513104  ·  dfillipiadis@yahoo.gr

Vasileios Balomenos, MD, MSc, PhD(c)  ·  +30645297496  ·  balomenosv@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Attikon University General HospitalAthens, GreeceRecruiting

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Source record: clinicaltrials.gov/study/NCT07425457