Condition: Depression - Major Depressive Disorder · Irritability · Depression · Sponsor: University of Oxford
The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1. How does fluoxetine affect responses to anger-related stimuli such as words, faces, and autobiographical recall? 2. How does fluoxetine influence responses during frustration induction in frustrative non-reward and threat paradigms? 3. Does the effect manifest in physiological markers, including heart rate variability and facial expressions? Researchers will compare fluoxetine to a placebo to see if drug fluoxetine affects anger processing. Participants will: Take 20mg fluoxetine or a placebo every day for 7 days. Visit the university site for questionnaire and tasks assessments. Heart rate variability and facial expressions will be recorded in some of the tasks.
This description comes directly from the study's public registry record.
Catherine Harmer, PhD · +441865 618326 · catherine.harmer@psych.ox.ac.uk
Ye Wo, MSc · +447564300004 · ye.wo@psych.ox.ac.uk
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| Department of Psychiatry, University of Oxford | Oxford, Oxfordshire, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07424781