Condition: Incisional Ventral Hernia · Sponsor: Northwestern University
This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure. The study includes three cohorts: 1) Healthy controls (N=5), 2) High-tension fascial closure AWR patients (N=10), 3) Low-tension fascial closure AWR patients (N=10). Fascial closure tension will not be altered for the purpose of the study and will be determined by the operating surgeon as part of routine clinical decision-making.
This description comes directly from the study's public registry record.
Megan Melland-Smith, MD · 312-907-1414 · megan.mellandsmith@nm.org
Nancy Ly, MD · 262-455-1560 · nancy.ly@nm.org
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| Northwestern Memorial Hospital | Chicago, Illinois, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07422584