Condition: Healthy · Brain Insulin Sensitivity · Cerebral Blood Flow · Sponsor: Maastricht University Medical Center
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation. It is therefore important to investigate the specific effects of walnuts on cerebral blood flow responses before and after intranasal insulin administration, as well as their associated functional benefits. The investigators hypothesize that long-term walnut consumption improves vascular function and insulin-sensitivity in the brain, thereby enhancing cognitive performance and appetite control in abdominally obese men and women. Objective: The primary objectives are to investigate in abdominally obese adults the effects of 24-week walnut consumption on (regional) vascular function and insulin-sensitivity in the brain, while the investigators will also assess changes in cognitive performance and appetite-related brain reward activity (secondary objectives). Cerebral blood flow responses before (brain vascular function) and after the administration of intranasal insulin spray (brain insulin-sensitivity) will be quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-perfusion method Arterial Spin Labeling (ASL). Study design: This intervention study will have a randomized, controlled parallel design. The total study duration will be 24 weeks. Study population: Fifty-five abdominally obese men and (postmenopausal) women (aged 45-75 years) without a history of cardiovascular …
This description comes directly from the study's public registry record.
Peter J. Joris, PhD · +31883887250 · p.joris@maastrichtuniversity.nl
Linda J. Kehr, MSc · +31433883931 · linda.kehr@maastrichtuniversity.nl
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| Maastricht University, Department of Nutrition and Movement Sciences | Maastricht, Limburg, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07422220