Condition: Urothelial Cancer · Advanced/Metastatic Urothelial Cancer · Urothelial Carcinoma · Sponsor: Pfizer
This study is being done to learn more about a new medicine called PF-08634404. It is for adults with a type of bladder cancer called locally advanced or metastatic urothelial cancer (LA/mUC), meaning the cancer has spread to nearby tissues or other parts of the body. The purpose of the study is to see if PF-08634404 is safe, how well it works, how it moves through the body, and how it affects the cancer. The study will also look at how the medicine may change certain markers in the body that are linked to cancer. To join the study, participants must: * Be adults (18 years or older) and * Have locally advanced or metastatic urothelial cancer, The study has two groups: * Cohort A: People who have already received treatment for their cancer will get the study medicine ( PF-08634404) alone. * Cohort B: People who have not had treatment before will get the study medicine along with another cancer medicine called enfortumab vedotin. Everyone in the study will get the study medicine through a vein (IV infusion) with or without enfortumab vedotin. Treatment will continue as long as it helps and side effects are manageable. Before starting, participants will go through a screening period to check if they are eligible. During the study, they will have regular visits for treatment, health checks, and tests to see how the cancer is responding. Scans will be done regularly to monitor the cancer. If the cancer gets worse but the treatment is still helping and side effects are mana…
This description comes directly from the study's public registry record.
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Always discuss trial participation with your own doctor first.
| Highlands Oncology Group, PA | Fayetteville, Arkansas, United States | Recruiting |
| Highlands Oncology Group, PA | Rogers, Arkansas, United States | Recruiting |
| Highlands Oncology Group, PA | Springdale, Arkansas, United States | Recruiting |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte, California, United States | Recruiting |
| City of Hope Investigational Drug Services (IDS) | Duarte, California, United States | Recruiting |
| City of Hope at Irvine Lennar | Irvine, California, United States | Recruiting |
| City of Hope Investigational Drug Service (IDS) | Irvine, California, United States | Recruiting |
| City of Hope-Long Beach (ELM) | Long Beach, California, United States | Recruiting |
| City of Hope UPLAND | Upland, California, United States | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Aurora, Colorado, United States | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Denver, Colorado, United States | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Lone Tree, Colorado, United States | Recruiting |
+ 103 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07421700