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Study identifier: NCT07417137 Synced from ClinicalTrials.gov · July 29, 2026
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A Natural History Study of Angelman Syndrome

Condition: Angelman Syndrome  ·  Sponsor: Massachusetts General Hospital

PhaseN/A
Planned participants40
Who can joinAll sexes, 1 Year to no upper limit
Healthy volunteersNo

About this study

The goal of this observational study is to learn about the natural progression of Angelman syndrome (AS) in children and adults with a confirmed genetic diagnosis of AS. The main questions it aims to answer are: * How do developmental skills, such as communication, motor abilities, and adaptive behaviors, change over a 1-year period in people with AS? * Are there specific patterns in brain activity or sleep that are associated with changes in AS symptoms over time? Participants will: * Visit the study site 5 times over 1 year (approximately every 3 months) for assessments. * Complete tests and questionnaires about development, behaviors, and sleep with the help of their caregivers. * Undergo electroencephalograms (EEGs) to measure brain activity and wear a sleep-monitoring device at home (to collect actigraphy data).

This description comes directly from the study's public registry record.

Talk to the study team

Caleb Weinstock  ·  781-860-1711  ·  MGHGLOW-AS@mgb.org

Leena Phan  ·  781-860-1711  ·  MGHGLOW-AS@mgb.org

Always discuss trial participation with your own doctor first.

Locations (1)

MGH Lurie Center for AutismLexington, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07417137