Condition: Erythrocyte Destruction · Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery. A red blood cell damage evaluation system based on multiple-dimensional indicators is established. Through atomic force microscopy, microfluidic chips and biochemical detection methods, the changes in red blood cell membrane structure, deformability and oxygen-carrying capacity under different irradiation doses are systematically evaluated. The dose-effect relationship between irradiation dose and red blood cell damage degree is clarified, providing experimental evidence for the safe dose of irradiation processing of autologous blood during surgery.
This description comes directly from the study's public registry record.
Fengjiang Zhang · +8613858007629 · zrzfj@zju.edu.cn
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| The Second Affiliated Hospital, School of Medicine, Zhejiang University,anesthesiology department, | Hangzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07416045