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Study identifier: NCT07415044 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Condition: Ulcerative Colitis (UC) · Ulcerative Colitis, Active Moderate · Ulcerative Colitis, Active Severe  ·  Sponsor: Eli Lilly and Company

PhasePhase 2
Planned participants1431
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally. The study will last up to approximately 108 weeks, excluding screening.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (258)

Valleywise Health Medical CenterPhoenix, Arizona, United StatesRecruiting
One of a Kind Clinical Research CenterScottsdale, Arizona, United StatesSuspended
Clinnova ResearchAnaheim, California, United StatesRecruiting
GMC Clinical ResearchFolsom, California, United StatesRecruiting
Om Research LLCTemple City, California, United StatesRecruiting
Om Research LLCVictorville, California, United StatesRecruiting
Peak Gastroenterology AssociatesColorado Springs, Colorado, United StatesRecruiting
Advanced Research Institute - DenverDenver, Colorado, United StatesSuspended
Rocky Mountain Gastroenterology Associates - LakewoodLakewood, Colorado, United StatesRecruiting
Medical Research Center of ConnecticutHamden, Connecticut, United StatesNot Yet Recruiting
K2 Medical Research - Daytona BeachDaytona Beach, Florida, United StatesRecruiting
Clinical Research of OsceolaKissimmee, Florida, United StatesRecruiting

+ 246 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07415044