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Study identifier: NCT07414446 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device

Condition: Hereditary Haemorrhagic Telangiectasia · PFO - Patent Foramen Ovale · Pulmonary Arteriovenous Malformation  ·  Sponsor: St. Antonius Hospital

PhaseNA
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn how well the SONAS ultrasound device can detect right-to-left shunts of adults with hereditary hemorrhagic telangiectasia (HHT) who are already scheduled for a contrast bubble echocardiogram (TTCE). The main questions it aims to answer are: 1. How accurately does SONAS detect right-to-left shunts compared to the standard TTCE test? 2. Can SONAS results help tell the difference between shunts in the heart and shunts in the lungs? Participants will wear a headband with the SONAS device on the head while they undergo their routine TTCE bubble test. They will receive the usual contrast (agitated saline) through a vein, and both SONAS and TTCE signals will be recorded at the same time. There will be one examination in rest, and one during a breathing exercise (the Valsalva manoeuvre).

This description comes directly from the study's public registry record.

Talk to the study team

Pier HJ van Veen, Medical Doctor  ·  0883205336  ·  ja.van.veen@antoniusziekenhuis.nl

Always discuss trial participation with your own doctor first.

Locations (1)

St. Antonius HospitalNieuwegein, Utrecht, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT07414446