Condition: Systemic Lupus Erythematosus (SLE) · Sjogren's Syndrome (SS) · Systemic Sclerosis (SSc) · Sponsor: Therorna
This is an open-label, dose escalation study in patients with relapsed and refractory autoimmune diseases. Study drug, TI-0032-III injection, is composed of lipid nanoparticles (LNPs) targeting T cells that encapsulate circular RNA encoding the CD19 chimeric antigen receptor (CAR), which is a therapeutic biological product. It is clinically intended for the treatment of various relapsed and refractory B cell-related autoimmune diseases, such as systemic lupus erythematosus, sjögren's syndrome, systemic sclerosis, idiopathic inflammatory myositis, and antiphospholipid syndrome.
This description comes directly from the study's public registry record.
Xiao bing Wang, PhD · 021-81886999 · gale820907@163.com
Hu ji Xu, PhD
Always discuss trial participation with your own doctor first.
| Shanghai Changzheng Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07413341