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Study identifier: NCT07412756 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

Condition: Depressive Disorder, Major  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants1000
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms. The trial is divided into three periods as follows: a screening period that will last approximately 1 month, a treatment period that will last a minimum of 12 months, and the follow up period that will last approximately 2 months. The duration of study participation may vary and may be shortened if depression symptoms worsen or if withdrawal from the study occurs for any reason.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (180)

Accellacare - MoorparkMoorpark, California, United StatesRecruiting
ATP Clinical ResearchOrange, California, United StatesRecruiting
Yale University School of MedicineNew Haven, Connecticut, United StatesRecruiting
Encore Medical ResearchHollywood, Florida, United StatesRecruiting
K2 Medical Research - MaitlandMaitland, Florida, United StatesRecruiting
Life Medical Research Group CorpMiami Gardens, Florida, United StatesRecruiting
Floridian Clinical Research, LLCMiami Lakes, Florida, United StatesRecruiting
CLA ResearchNaples, Florida, United StatesRecruiting
Optimal Research SitesOrange City, Florida, United StatesRecruiting
Charter Research - OrlandoOrlando, Florida, United StatesRecruiting
K2 Medical Research - TampaTampa, Florida, United StatesRecruiting
CenExel iResearch, LLCDecatur, Georgia, United StatesRecruiting

+ 168 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07412756