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Study identifier: NCT07412444 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

EVOO and Metabolic Liver Health in MASLD

Condition: MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease · Overweight  ·  Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

PhaseNA
Planned participants60
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersYes

About this study

MASLD is currently one of the most common chronic non-communicable diseases and the leading cause of liver-related mortality and morbidity, with a rising prevalence worldwide, especially in the presence of obesity, diabetes, and other cardio-metabolic risk factors. Lifestyle modification, particularly through the Mediterranean Diet, is the first-line intervention, and extra virgin olive oil is a key component thanks to its monounsaturated fatty acids and bioactive compounds with anti-inflammatory and antioxidant effects. Several studies indicate that extra virgin olive oil supplementation, especially within a Mediterranean Diet pattern, reduces hepatic steatosis, improves inflammation, oxidative stress, and glucose and lipid profiles, and may promote weight loss and reduction of fat mass, also through potential effects on the gut microbiota. EFSA recognizes protective effects with a daily intake of at least 20 g of extra virgin olive oil, but it is still unclear whether this amount is optimal for individuals with MASLD, particularly those who are overweight or obese

This description comes directly from the study's public registry record.

Talk to the study team

Rossella Tatoli, Dietician  ·  +390804994652  ·  rossella.tatoli@irccsdebellis.it

Rossella Donghia, Biologist  ·  +390804994652  ·  rossella.donghia@irccsdebellis.it

Always discuss trial participation with your own doctor first.

Locations (1)

UOS Data ScienceCastellana Grotte, Italy, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07412444