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Study identifier: NCT07410520 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

PD-1 Inhibitor Combined With Rituximab, Methotrexate, and Orelabrutinib (PD-1i+RMO) for Newly Diagnosed PCNSL and SCNSL.

Condition: Primary Central Nervous System Lymphoma (PCNSL) · Secondary Central Nervous System Lymphoma (SCNSL)  ·  Sponsor: The First Affiliated Hospital with Nanjing Medical University

PhasePhase 2
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multicenter, open-label, single-arm, prospective clinical study of PD-1 inhibitor combined with rituximab, methotrexate, and orelabrutinib (PD-1i+RMO) in the treatment of newly diagnosed primary central nervous system lymphoma (ND-PCNSL) and secondary central nervous system lymphoma (SCNSL). The primary endpoint is 1-year progression-free survival (PFS).

This description comes directly from the study's public registry record.

Talk to the study team

Lei Fan  ·  +8613813976136  ·  fanlei3014@126.com

Always discuss trial participation with your own doctor first.

Locations (1)

The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07410520