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Study identifier: NCT07410156 Synced from ClinicalTrials.gov · July 28, 2026
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Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.

Condition: Gingival Pigmentation · Gingival Hyperpigmentaion  ·  Sponsor: Fayoum University

PhaseNA
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

The present study will be carried to evaluate the efficacy of MN technique with topical Silymarin application in treating gingival hyperpigmentation in comparison with Laser and scalpel methods. This evaluation will be done clinically. The questions to be answered: * Is there a statistical difference between the microneedling (MN) technique with topical silymarin application, the scalpel technique, and the diode laser in providing clinical and aesthetic advantages in the treatment of gingival pigmentation? * What medical problems do participants have when using of Silymarin topically? Participants will be: Group 1 : The gingiva of the facial surfaces of the selected area will be de-epithelized by conventional method through blades no 15c. Group 2 : The gingiva of the facial surfaces of the selected area will be de-epithelized by A Diode laser Device (serolaser). Group 3 : The gingiva of the facial surfaces of the selected area will be treated by repetitive punctures with Dr.Pen ULTIMA - A6 needle tip. Silymarin is applied topically for ten minutes.

This description comes directly from the study's public registry record.

Talk to the study team

Tarek Taha TTAAbdeltawab, Researcher  ·  +201100892663  ·  tt1139@fayoum.edu.eg

Rehab Ahmed Osman, Lecturer  ·  +201096992996  ·  rau11@fayoum.edu.eg

Always discuss trial participation with your own doctor first.

Locations (1)

Fayoum University, Faculty of Dentistry, Department of Oral Medicine and PeriodontologyAl Fayyum, EgyptRecruiting

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Source record: clinicaltrials.gov/study/NCT07410156