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Study identifier: NCT07406633 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

Condition: GIST - Gastrointestinal Stromal Tumor · GIST · GIST Metastatic Cancer  ·  Sponsor: Kumquat Biosciences Inc.

PhasePhase 2
Planned participants46
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at treating GIST. Imatinib has been approved by the FDA for the treatment of different types of cancer including GIST.

This description comes directly from the study's public registry record.

Talk to the study team

Kumquat Clinical Development  ·  858-214-2700  ·  kumquatstudies@kumquatbio.com

Always discuss trial participation with your own doctor first.

Locations (16)

USC Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
Mayo Clinic - JacksonvilleJacksonville, Florida, United StatesRecruiting
Sylvester Comprehensive Cancer CenterMiami, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
University of Chicago Medical CenterChicago, Illinois, United StatesRecruiting
University of Iowa Health CareIowa City, Iowa, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
University of Michigan HospitalsAnn Arbor, Michigan, United StatesRecruiting
Mayo Clinic - RochesterRochester, Minnesota, United StatesRecruiting
Northwell Health/R.J. Zuckerberg Cancer CenterLake Success, New York, United StatesRecruiting
University of North Carolina at Chapel HillChapel Hill, North Carolina, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07406633