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Study identifier: NCT07406217 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients

Condition: COVID-19 · Immunodeficiency  ·  Sponsor: Calmy Alexandra

PhasePhase 2
Planned participants256
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersNo

About this study

The overall purpose of the trial is to evaluate the efficacy and safety of possible combination antiviral therapy direct antiviral agents (remdesivir + nirmatrelvir/r) versus the reference monotherapy (nirmatrelvir/r alone) and to assess the efficacy and safety of increasing the nirmatrelvir/r course from 5- to 10 days in immunocompromised patients diagnosed with asymptomatic or mild to moderate Coronavirus Disease 2019 (COVID-19).

This description comes directly from the study's public registry record.

Talk to the study team

Alexandra Calmy, MD PhD  ·  +41 22 372 98 12  ·  alexandra.calmy@hug.ch

Chiara Fedeli, PhD  ·  +41 (0)22 372 9817  ·  chiara.fedeli@hug.ch

Always discuss trial participation with your own doctor first.

Locations (4)

Basel University HospitalBasel, Basel, SwitzerlandRecruiting
Hôpitaux Universitaires de GenèveGeneva, Canton of Geneva, SwitzerlandRecruiting
CHUVLausanne, Canton of Vaud, SwitzerlandRecruiting
University Hospital ZurichZurich, Canton of Zurich, SwitzerlandRecruiting

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Source record: clinicaltrials.gov/study/NCT07406217