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Study identifier: NCT07405801 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Condition: Breast Cancer  ·  Sponsor: Hoffmann-La Roche

PhasePhase 2
Planned participants80
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A study to evaluate the efficacy and safety of triplet combination of inavolisib plus ribociclib and fulvestrant versus placebo plus ribociclib and fulvestrant in the first-line setting in participants with endocrine-therapy-resistant hormone receptor (HR)-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC).

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: CO46274 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (49)

Avera Cancer Institute - MarshallMarshall, Minnesota, United StatesRecruiting
Avera Cancer Institute - AberdeenAberdeen, South Dakota, United StatesRecruiting
Avera Cancer Institute - MitchellMitchell, South Dakota, United StatesRecruiting
Avera Cancer Institute - Pierre, SDPierre, South Dakota, United StatesRecruiting
Avera Cancer InstituteSioux Falls, South Dakota, United StatesRecruiting
AMG Oncology and Hematology Avera Cancer Institute - YanktonYankton, South Dakota, United StatesRecruiting
Inst. Alexander FlemingBuenos Aires, ArgentinaRecruiting
Centro Oncologico KorbenCaba, ArgentinaRecruiting
Centro Médico FleischerCapital Federal, ArgentinaRecruiting
Sanatorio de la MujerRosario, ArgentinaRecruiting
Hospital Santa Rita de Cassia VitoriaVitória, Espírito Santo, BrazilRecruiting
Hospital BrasiliaBrasília, Federal District, BrazilRecruiting

+ 37 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07405801