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Study identifier: NCT07405476 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment

Condition: Colon Carcinoma · Colorectal Carcinoma · Rectal Carcinoma  ·  Sponsor: Emory University

PhasePhase 2
Planned participants38
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial studies how well giving zanidatamab before surgery (neoadjuvant) works in treating patients with colon and rectal cancer that is human epidermal growth factor receptor 2 positive (HER2+ve) who are planned for curative intent treatment. Zanidatamab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens).

This description comes directly from the study's public registry record.

Talk to the study team

Olumide B. Gbolahan, MBBS, MSc  ·  404-778-1900  ·  ogbolah@emory.edu

Patrick Sullivan, MD, FACS  ·  404-778-2656  ·  patrick.s.sullivan@emory.edu

Always discuss trial participation with your own doctor first.

Locations (4)

Emory University Hospital MidtownAtlanta, Georgia, United StatesRecruiting
Emory University HospitalAtlanta, Georgia, United StatesRecruiting
Emory Saint Joseph's HospitalAtlanta, Georgia, United StatesRecruiting
Emory Decatur HospitalDecatur, Georgia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07405476