Condition: Von Hippel-Lindau Disease · Malignant Neoplasms · Sponsor: Merck Sharp & Dohme LLC
Researchers are looking for new ways to treat advanced solid tumors and von Hippel-Lindau (VHL)-related tumors: * Advanced means the cancer has spread to other parts of the body (metastatic) or cannot be removed with surgery * Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids * VHL-related tumors are tumors caused by VHL disease. VHL disease is passed down from parents to children and people with VHL disease have a higher chance of getting certain types of cancer Researchers want to learn about the long-term effects of a trial medicine called belzutifan. Belzutifan, also called MK-6482, is designed to block a protein that helps tumors grow and survive. This is an extension trial, which means only people who were in certain other belzutifan trials (called parent trials) may be able to join. The goal of this trial is to learn how long people live after they start taking belzutifan.
This description comes directly from the study's public registry record.
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| Beth Israel Deaconess Medical Center ( Site 0107) | Boston, Massachusetts, United States | Recruiting |
| Dana-Farber Cancer Institute ( Site 0105) | Boston, Massachusetts, United States | Recruiting |
| Karmanos Cancer Center ( Site 0108) | Detroit, Michigan, United States | Recruiting |
| Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine ( Site 0100) | Philadelphia, Pennsylvania, United States | Recruiting |
| SCRI Oncology Partners ( Site 7000) | Nashville, Tennessee, United States | Recruiting |
| START San Antonio ( Site 0104) | San Antonio, Texas, United States | Recruiting |
| Fred Hutchinson Cancer Center ( Site 0106) | Seattle, Washington, United States | Recruiting |
| St George Hospital-Oncology Clinical Research Unit ( Site 2701) | Kogarah, New South Wales, Australia | Recruiting |
| Westmead Hospital ( Site 2703) | Sydney, New South Wales, Australia | Recruiting |
| UZ Leuven ( Site 0900) | Leuven, Vlaams-Brabant, Belgium | Recruiting |
| BP - A Beneficencia Portuguesa de São Paulo ( Site 0200) | São Paulo, São Paulo, Brazil | Recruiting |
| Département clinique de médecine de laboratoire du CHUM ( Site 0001) | Montreal, Quebec, Canada | Active Not Recruiting |
+ 37 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07405164