Condition: Non Small Cell Lung Cancer · Pulmonary Stereotactic Radiotherapy · Sponsor: Istituto Clinico Humanitas
Radiotherapy (radiation treatment) is often used to treat lung cancers and lung tumors that have spread from other cancers. It can be very effective, especially in early-stage lung cancer or when there are only a few tumor sites. Even so, some patients later develop a local recurrence, meaning the cancer comes back in the same area that was previously treated with radiation. When this happens, treatment options are limited. Surgery can sometimes remove the recurrent tumor, but many patients are not able to have surgery because of their general health or because the tumor is difficult to remove. For these patients, a second course of radiotherapy (called re-irradiation) may be the only possible treatment. One type of radiotherapy, called stereotactic body radiotherapy (SBRT), delivers very high doses of radiation very precisely. SBRT has been used successfully as a second treatment after standard radiotherapy in some patients. However, there is very little information about using SBRT again in patients who already received SBRT the first time. Because only small studies have been done and the patients were very different from each other, doctors still do not know enough about how safe and effective a second SBRT treatment is. In particular, it is still unclear whether giving another high-dose radiation treatment is possible without causing serious side effects. More research is needed to better understand this option and help guide treatment decisions for patients.
This description comes directly from the study's public registry record.
Davide Franceschini, MD, radiation oncologist · +39 0282247428 · davide.franceschini@cancercenter.humanitas.it
Laura Bonavita, master degree · +39 0282247026 · laura.bonavita@humanitas.it
Always discuss trial participation with your own doctor first.
| AST Papa Giovanni XXIII | Bergamo, Bergamo, Italy | Recruiting |
| Radiotherapy Department, Ospedale Bellaria Carlo Alberto Pizzardi | Bologna, Bologna, Italy | Not Yet Recruiting |
| REM Radioterapia | Catania, Catania, Italy | Not Yet Recruiting |
| Radiation oncology unit, Ospedale San Raffaele | Milan, Milano, Italy | Not Yet Recruiting |
| Radiotherapy Department, Istituto Europeo di Oncologia | Milan, Milano, Italy | Not Yet Recruiting |
| IRCCS Humanitas Research Hospital | Rozzano, Milano, Italy | Recruiting |
| Radiotherapy Department, IRCCS Istituto Nazionale Fondazione G. Pascale | Naples, Napoli, Italy | Not Yet Recruiting |
| Centro Fondazione Policlinico Universitario "A. Gemelli", Radioterapia Oncologica | Roma, Roma, Italy | Not Yet Recruiting |
| Radioterapia Oncologica - Ospedale dell'Angelo | Venezia, Venezia, Italy | Not Yet Recruiting |
| Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center | Negrar, Verona, Italy | Not Yet Recruiting |
| AOUI Verona, DAI Chirurgia e Oncologia - Radioterapia Oncologica | Verona, Verona, Italy | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07401615