Condition: Post-Acute COVID-19 Vaccination Syndrome · Postviral Fatigue · Sponsor: University of Bern
Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions. This condition is known as Post-Acute COVID-19 Vaccination Syndrome (PACVS). Symptoms can persist for months and affect several organ systems, causing issues such as fatigue, heart-related problems, neurological difficulties, and decreases in both physical ability and mental performance. PACVS shows similarities to Post-Acute COVID-19 syndrome (PACS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The biological processes that cause PACVS are still not fully understood. Recent research indicates that endothelial dysfunction, abnormalities in blood coagulation, and persistent inflammatory responses may contribute significantly to this process. However, it remains unclear how symptoms develop over time, which biological markers are associated with disease severity, and how these findings could support diagnosis and future treatment strategies. The CLEAR study is an observational research project designed to address these knowledge gaps by systematically documenting symptoms over time and investigating potential biological correlates in individuals affected by PACVS. The study consists of three complementary subprojects. The PROGRESS subproject aims to assess symptom burden, disease course, and patient-reported treatment experiences over an…
This description comes directly from the study's public registry record.
Mirko Schmidt, Prof. Dr. · +41 79 342 67 30 · CLEAR.ispw@unibe.ch
Michaela Fux, PD Dr. phil. nat. · +41 79 342 67 30 · CLEAR.ispw@unibe.ch
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| Institute of Sport Science, University of Bern | Bern, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07400848