Condition: Hemorrhoids · Postoperative Pain · Sponsor: Lomonosov Moscow State University Medical Research and Educational Center
Hemorrhoidectomy is an effective surgical treatment for advanced hemorrhoidal disease but is often associated with significant postoperative pain, which may delay recovery. One of the main contributors to pain after hemorrhoidectomy is spasm and increased tone of the internal anal sphincter. This randomized, double-blind, placebo-controlled clinical trial evaluates whether preoperative injection of botulinum toxin type A into the internal anal sphincter, performed seven days before hemorrhoidectomy, can reduce postoperative pain compared with placebo. Adult patients with grade III-IV hemorrhoids scheduled for excisional hemorrhoidectomy will be randomized to receive either botulinum toxin A or saline injection prior to surgery. Postoperative pain intensity, analgesic consumption, complications, functional outcomes, and patient satisfaction will be assessed during the first 30 days after surgery.
This description comes directly from the study's public registry record.
Tatiana Garmanova, MD, PhD · + 7 977 342 92 49 · tatianagarmanova@gmail.com
Aleksandr Lukianov, MD · + 7 916 772 93 03 · alexmaxl1225469@gmail.com
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| Lomonosov Moscow State University Medical Research and Educational Center | Moscow, Moscow, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07399860