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Study identifier: NCT07397611 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

Condition: Renal Cell Carcinoma · Kidney Cancer · Kidney Neoplasm  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 2
Planned participants32
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to see whether the drug casdatifan is safe and effective either by itself or in combination with the drug zimberelimab in participants with resectable clear cell renal cell carcinoma (ccRCC). The names of the study drugs involved in this study are: * Casdatifan (a type of HIF-2α inhibitor) * Zimberelimab (a type of monoclonal antibody)

This description comes directly from the study's public registry record.

Talk to the study team

Wenxin Xu, MD  ·  617-632-6534  ·  Wenxin_Xu1@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesNot Yet Recruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07397611