Condition: Lichen Plano-Pilaris · Sponsor: The Skin Center Dermatology Group
Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia characterized by progressive, permanent hair loss and scalp symptoms such as pruritus and burning. Current treatments-including topical and intralesional corticosteroids, hydroxychloroquine, and immunosuppressants-are often inadequate, with limited evidence for efficacy and frequent treatment switching or discontinuation due to side effects or lack of response.1,2 Recent systematic reviews and meta-analyses highlight the need for new, targeted therapies. 3,4 Nemolizumab, an IL-31 receptor antagonist, FDA-approved for prurigo nodularis and atopic dermatitis, has demonstrated efficacy in pruritic and fibrosing dermatoses, making it a rational candidate for LPP.
This description comes directly from the study's public registry record.
Peter Friedman, MD PhD · 8453520500 · drfriedman@skincenterderm.com
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| The Skin Center Dermatology Group | New City, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07396168