Condition: Spine Degeneration · Lumbar Degenerative Disease · Frail Elderly · Sponsor: Xuanwu Hospital, Beijing
This multicenter, parallel-group, assessor-blinded randomized controlled trial will enroll 248 adults aged ≥75 years with degenerative lumbar spinal diseases scheduled for elective lumbar fusion surgery, and they will be randomized 1:1 into the intervention and usual care groups. The intervention group will receive a 6-week PHYSIO-Prehab multimodal prehabilitation program, including multicomponent exercise, nutritional intervention, comorbidity optimization, and cognitive prehabilitation with brain protection strategies. The control group will receive standard health education provided via a manual, and both groups will receive consistent perioperative Enhanced Recovery After Surgery care. The primary outcome will be the change in Barthel Index (a tool for assessing independence in activities of daily living) from baseline to 30 days postoperatively; secondary outcomes will include pain scores, disability, patient satisfaction, and the 30-day postoperative Comprehensive Complication Index. The trial will initiate recruitment in April 2026 and conclude in December 2027, aiming to evaluate the feasibility and efficacy of PHYSIO-Prehab and provide high-quality evidence for patient-centered perioperative care pathways in this population.
This description comes directly from the study's public registry record.
Shuaikang Wang, MD · 15804084262 · jackwangDR@163.com
Shibao Lu, Ph.D., MD · 18301680586 · 2984335856@163.com
Always discuss trial participation with your own doctor first.
| Xuanwu hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Beijing Friendship Hospital of Capital Medical University | Beijing, China | Recruiting |
| Department of Orthopedics, the Seventh Mecical Center of PLA General Hospital | Beijing, China | Recruiting |
| Peking University First Hospital | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07396077