Condition: Male Contraception · Semen Volume · Sperm Motility · Sponsor: Next Life Sciences
NLS-133-CLIN001 is a Phase 2a study designed to assess the safety, tolerability, and effects of NLS-133 (combination of two FDA-approved agents) compared to an active control (FDA-approved pharmacologic agent) or placebo on semen volume and sperm count in 10 in healthy men. Participants will be randomized in a crossover design to receive a single dose of NLS-133, an active control or placebo either 90 or 180 minutes prior to collection of semen. Sperm parameters measured will be count, motility and morphology. A brief questionnaire will be completed by each subject during each treatment cycle that addresses orgasm and ejaculation quality. Safety monitoring will include adverse event reporting, laboratory assessments, and vital signs.
This description comes directly from the study's public registry record.
John K Amory, MD, MPH, MSc · (206) 616-1727 · jamory@uw.edu
Always discuss trial participation with your own doctor first.
| Population Center for Research in Human Reproduction and Departments of Medicine, University of Washington | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07393334