Condition: Anatomic Stage II Breast Cancer AJCC v8 · Anatomic Stage IIIA Breast Cancer AJCC v8 · Anatomic Stage IIIC Breast Cancer AJCC v8 · Sponsor: National Cancer Institute (NCI)
This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the cancer returning (low risk recurrence). Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy, with letrozole, anastrozole or exemestane, lowers the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hormone therapy plus ribociclib may work as well as chemotherapy followed by hormone therapy plus ribociclib for the treatment of high anatomic stage breast cancer with low recurrence risk.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | Recruiting |
| Palo Alto Medical Foundation Health Care | Palo Alto, California, United States | Recruiting |
| Sutter Roseville Medical Center | Roseville, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| California Pacific Medical Center-Pacific Campus | San Francisco, California, United States | Recruiting |
| Mills Health Center | San Mateo, California, United States | Recruiting |
| Sutter Solano Medical Center/Cancer Center | Vallejo, California, United States | Recruiting |
| Stamford Hospital/Bennett Cancer Center | Stamford, Connecticut, United States | Recruiting |
| Helen F Graham Cancer Center | Newark, Delaware, United States | Recruiting |
| Medical Oncology Hematology Consultants PA | Newark, Delaware, United States | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene, Idaho, United States | Recruiting |
+ 60 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07391774