Condition: Erectile Dysfunctions · Sponsor: Mansoura University
The goal of this clinical trial is to evaluate whether daily dosing with tadalafil 5 mg combined with on-demand sildenafil 100 mg can improve erectile function in men with erectile dysfunction (ED) who do not respond to PDE5 inhibitor alone. The main questions it aims to answer are: * Does the combination of daily tadalafil and on-demand sildenafil lead to a greater improvement in erectile function (measured by the IIEF-EF domain) compared with on-demand sildenafil alone? * Is the combination therapy safe and well tolerated in this patient population? Researchers will compare: * Group A: Daily tadalafil 5 mg plus on-demand sildenafil 100 mg * Group B: Daily placebo plus on-demand sildenafil 100 mg to determine whether the combination regimen provides superior improvement in erectile function and patient satisfaction. Participants will: * Undergo baseline assessment including medical history, physical examination, and laboratory tests. * Be randomly assigned to one of the two treatment groups. * Take the assigned medications for 12 weeks. * Complete follow-up evaluations at 4, 8, and 12 weeks, including: International Index of Erectile Function (IIEF-15) questionnaire Erection Hardness Score (EHS) assessment Reporting of any adverse effects
This description comes directly from the study's public registry record.
Ahmed A Shokeir+2, professor of Urology · +201121102929 · ahmed.shokeir@hotmail.com
Always discuss trial participation with your own doctor first.
| Urology and Nephrology Center, Mansoura University | Al Mansurah, Dakahlia Governorate, Egypt | Recruiting |
| Faculty of medicine, Alexandria University | Alexandria, Egypt | Recruiting |
| Faculty of medicine, Aswan university | Aswān, Egypt | Recruiting |
| Faculty of Medicine - Assiut University | Asyut, Egypt | Recruiting |
| Cairo University, faculty of medicine | Cairo, Egypt | Recruiting |
| Faculty of medicine, Ain Shams University | Cairo, Egypt | Recruiting |
| Faculty of medicine, Azhar University | Cairo, Egypt | Recruiting |
| Faculty of medicine, october 6 Univeristy | Cairo, Egypt | Recruiting |
| Faculty of medicine, Luxor university | Luxor, Egypt | Recruiting |
| faculty of medicine, Minya University | Minya, Egypt | Recruiting |
| Faculty of medicine, Tanta University | Tanta, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07391579