Condition: Radiation-induced Lung Injury · Immune-related Pneumonia · Sponsor: Beijing Continent Pharmaceutical Co, Ltd.
Radiation-induced lung injury (RILI) is one of the most common thoracic-radiotherapy complications, with an incidence as high as 31.4 %. Multiple studies have shown that RILI can adversely affect patient prognosis by disrupting treatment schedules. Moreover, the widespread clinical use of immune-checkpoint inhibitors (ICIs) has further increased pulmonary toxicity when radiotherapy (RT) is combined with ICIs. Checkpoint-inhibitor-related pneumonitis (CIP)-i.e., immune-mediated lung injury-may necessitate permanent discontinuation of ICIs, diminish survival benefit, and, in severe cases, directly threaten life. The diagnosis of both RILI and CIP is based on an integrated assessment of subjective symptoms and imaging findings.RILI typically occurs 1-3 months after completion of radiotherapy, whereas CIP may emerge at any point during treatment. The two entities share similar clinical presentations: fever, dry cough, chest tightness, dyspnoea, and pleuritic chest pain. Computed tomography (CT) is the most sensitive imaging modality. Pulmonary-function testing is another routinely used clinical metric; vital capacity, total lung capacity, forced expiratory volume in 1 s (FEV₁), and diffusing capacity of the lung for carbon monoxide (DLCO) may all decline, with DLCO being the most sensitive parameter. In advanced cases, arterial oxygen and carbon-dioxide tensions may also deteriorate.Currently, RILI is managed empirically with systemic corticosteroids and supportive care; however,…
This description comes directly from the study's public registry record.
Ming Chen · 13600470913 · chenming@sysucc.org.cn
Always discuss trial participation with your own doctor first.
| Anhui Provincial Chest Hospital | Hefei, Anhui, China | Recruiting |
| Chinese Academy of Medical Sciences Cancer Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Affiliated Hospital of Fujian Medical University, Xiehe Branch | Fuzhou, Fujian, China | Recruiting |
| Fujian Provincial Cancer Hospital | Fuzhou, Fujian, China | Recruiting |
| Lanzhou University First Hospital | Lanzhou, Gansu, China | Recruiting |
| Foshan First Hospital | Foshan, Guangdong, China | Recruiting |
| Guangdong Provincial People's Hospital | Guangzhou, Guangdong, China | Recruiting |
| Panyu Central Hospital Affiliated to Guangzhou Medical University | Guangzhou, Guangdong, China | Recruiting |
| Southern Medical University - Southern Hospital | Guangzhou, Guangdong, China | Recruiting |
| Sun Yat-sen University Cancer Center | Guangzhou, Guangdong, China | Recruiting |
| The First Affiliated Hospital of Guangzhou University of Chinese Medicine | Guangzhou, Guangdong, China | Recruiting |
| The First Affiliated Hospital of Sun Yat-sen University | Guangzhou, Guangdong, China | Recruiting |
+ 24 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07388680