Condition: Constipation - Functional · Fecal Microbiota Transplantation (FMT) · Chronic Constipation · Sponsor: Peking Union Medical College Hospital
Chronic constipation is a common gastrointestinal disease with a global prevalence of about 15%, significantly affecting daily life and quality of life. Traditional treatments primarily rely on laxatives, which may lead to adverse effects with prolonged use, while surgical interventions have limited patient acceptance. Recent studies indicate that gut microbiota therapies-including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT)-can effectively manage chronic constipation. This study aims to investigate the safety and efficacy of FMT combined with a prebiotic nutritional intervention (using a co-localization strategy) in the treatment of functional constipation. Additionally, the investigators will explore changes in fecal microbiota and metabolomic profiles following the treatment.
This description comes directly from the study's public registry record.
Pengguang Yan · +8618810309887 · pengchengf@mail.sdu.edu.cn
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| Peking Union Medical College Hospital | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07387952