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Study identifier: NCT07387367 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

Condition: Adenovirus Infections  ·  Sponsor: SymBio Pharmaceuticals

PhasePhase 3
Planned participants180
Who can joinAll sexes, 2 Months to no upper limit
Healthy volunteersNo

About this study

This randomized, open-label, parallel group, two-arm, multi-center assessment will compare IV BCV with IV CDV in adult and pediatric allogeneic HCT recipients with AdV viremia. A virologic response-driven approach to duration of treatment will be evaluated, in which randomized subjects are treated with either BCV or CDV until AdV viremia is confirmed as undetectable or until a maximum of 12 weeks of therapy, whichever occurs first. All subjects will be followed for a total of 24 weeks post-randomization, regardless of treatment assignment. Subjects will be assessed on a weekly basis through the end of treatment visit (EOT). Additional assessments will be performed at the test of cure (TOC) visit, which is 4 weeks after the last dose of study drug and at Weeks 12 and 24 post W1D1.

This description comes directly from the study's public registry record.

Talk to the study team

Rochelle Maher  ·  +1-917-656-6951  ·  MedInfo@symbiopharma.com

Always discuss trial participation with your own doctor first.

Locations (81)

Phoenix Children's HospitalPhoenix, Arizona, United StatesRecruiting
City of HopeDuarte, California, United StatesNot Yet Recruiting
Stanford Medicine Children's HealthPalo Alto, California, United StatesNot Yet Recruiting
University of California DavisSacramento, California, United StatesRecruiting
Rady Children's HospitalSan Diego, California, United StatesNot Yet Recruiting
Children's Hospital Colorado-Center for Cancer and Blood DisordersAurora, Colorado, United StatesNot Yet Recruiting
Children's National HospitalWashington D.C., District of Columbia, United StatesRecruiting
Johns Hopkins All Children's HospitalSt. Petersburg, Florida, United StatesNot Yet Recruiting
Children's Healthcare of AtlantaAtlanta, Georgia, United StatesNot Yet Recruiting
Ann and Robert H Lurie Children's HospitalChicago, Illinois, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesNot Yet Recruiting
Riley Children's Health (Indiana University)Indianapolis, Indiana, United StatesNot Yet Recruiting

+ 69 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07387367