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Study identifier: NCT07383818 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Neoadjuvant Therapy Combined With Trastuzumab Rezetecan and Toripalimab for HR+/HER2-low Breast Cancer (NEOTORCH-BREAST 08)

Condition: HR Positive/HER2 Low Breast Cancer  ·  Sponsor: First Affiliated Hospital of Zhejiang University

PhasePhase 2
Planned participants111
Who can joinFemale, 18 Years to 70 Years
Healthy volunteersNo

About this study

This study is a prospective, multi-cohort, multicenter, open-label exploratory clinical trial. The primary study objective is to evaluate the pathologic complete response (PCR) of treatment of HR+/HER2-low breast cancer with neoadjuvant therapy combined with Trastuzumab Rezetecan and Toripalimab , including the incidences and types of adverse events. The secondary endpoints include event-free survival (EFS), residual cancer burden (RCB), and objective response rate (ORR).

This description comes directly from the study's public registry record.

Talk to the study team

Zhijun Dai  ·  +86 157 0581 9132  ·  dzj0911@126.com

Wanting Shao  ·  +86 13777556621  ·  shaowt111@163.com

Always discuss trial participation with your own doctor first.

Locations (5)

Harbin Medical University Cancer HospitalHarbin, ChinaRecruiting
The First Affiliated Hospital of Anhui Medical UniversityHefei, ChinaRecruiting
Zhongshan Hospital, Fudan UniversityShanghai, ChinaRecruiting
The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an, ChinaRecruiting
The Second Affiliated Hospital of Xi'an Jiaotong UniversityZhengzhou, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07383818