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Study identifier: NCT07380217 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Use of Mechanical Left ventricuLar Unloading in Complex Higher-risk Indicated Procedures

Condition: High-risk PCI · Coronary Artery Disease Risk High  ·  Sponsor: Amsterdam UMC, location VUmc

PhaseNA
Planned participants98
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

If there is a narrowing or blockage in the coronary arteries of the heart, the cardiologist may choose to treat this blockage. This is called percutaneous coronary intervention (PCI), which involves both balloon angioplasty and the placement of a stent. PCI is a commonly performed and safe procedure. However, in your case, the procedure is more complicated than usual due to the location and nature of the narrowing, the required technique for the intervention, and the fact that your heart function is reduced. As a result, your PCI will carry a higher risk than usual. During the procedure, balloons are inflated to clear the blockage, and a stent is placed to keep the artery open. This temporarily reduces or even stops the blood and oxygen supply to a large portion of the heart. This moment presents a higher risk for complications, such as low blood pressure or cardiac arrest. As a result, the heart may not pump blood effectively throughout the body, which can lead to oxygen deprivation in other organs. To help the heart in this situation, it is possible to insert a mechanical heart pump during the procedure. This form of support is introduced via an artery in the groin into your left ventricle. The pump helps the heart function and may improve the circulation to the body's organs. On the other hand, the placement of the pump increases the chance of complications. Therefore, there are both potential benefits and risks. It is currently unclear whether PCI with the temporary pum…

This description comes directly from the study's public registry record.

Talk to the study team

Alexander Nap, MD, PhD  ·  0031 020 444 4445  ·  a.nap@amsterdamumc.nl

Tijmen H. Ris, MD  ·  0031 020 444 4445  ·  t.h.ris@amsterdamumc.nl

Always discuss trial participation with your own doctor first.

Locations (8)

Amsterdam University Medical CenterAmsterdam, NetherlandsRecruiting
ZuyderlandGeleen, NetherlandsRecruiting
University Medical Center GroningenGroningen, NetherlandsRecruiting
Leiden University Medical CenterLeiden, NetherlandsRecruiting
Maastricht University Medical CenterMaastricht, NetherlandsRecruiting
Radboud University Medical CenterNijmegen, NetherlandsRecruiting
Haaglanden Medical CenterThe Hague, NetherlandsRecruiting
University Medical Center UtrechtUtrecht, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT07380217