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Study identifier: NCT07379580 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa

Condition: Mpox (Monkeypox) · Smallpox · Orthopoxvirus Infection  ·  Sponsor: BioNTech SE

PhasePhase 2
Planned participants310
Who can joinAll sexes, 18 Years to 64 Years
Healthy volunteersYes

About this study

This is a randomized, double-blind, placebo-controlled study which aims to assess the safety, reactogenicity, and immunogenicity after one and two doses of BNT166a or placebo in healthy participants.

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information  ·  +49 6131 9084  ·  patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (6)

University of Kinshasa UNIKINKinshasa, Democratic Republic of the CongoRecruiting
Institute National de Recherche BiomedicaleKinshasa, Democratic Republic of the CongoNot Yet Recruiting
TASK Applied ScienceCape Town, South AfricaRecruiting
TREAD Research Pty LtdCape Town, South AfricaRecruiting
Desmond Tutu Health Foundation Masiphumelele ClinicCape Town, South AfricaRecruiting
Perinatal HIV Research UnitJohannesburg, South AfricaRecruiting

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Source record: clinicaltrials.gov/study/NCT07379580