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Study identifier: NCT07379476 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Local Ablative Therapy to Oligoresidual Metastasis in EGFR Mutated Non-small Cell Lung Cancer

Condition: Lung Cancer (NSCLC)  ·  Sponsor: Chinese University of Hong Kong

PhasePhase 2
Planned participants64
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, multicentre, randomized phase II clinical trial. Patients with stage IV (AJCC 9th edition) non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or exon 21 L858R mutation, who had less than or equal to 3 active oligoresidual cancer sites amenable to local ablative therapy (LAT) (as determined by physician) after 3-6 months of firstline osimertinib treatment, are eligible. Subjects will be randomized 1:1 to osimertinib with or without LAT.

This description comes directly from the study's public registry record.

Talk to the study team

Molly SC LI, MBBS, MRCP  ·  3505 1042  ·  molly@clo.cuhk.edu.hk

Always discuss trial participation with your own doctor first.

Locations (1)

Department of Clinical Oncology, Prince of Wales HospitalHong Kong, Hong KongRecruiting

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Source record: clinicaltrials.gov/study/NCT07379476