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Study identifier: NCT07379125 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Therapeutic RSK1 Targeting in Myelofibrosis

Condition: Myelofibrosis  ·  Sponsor: Washington University School of Medicine

PhasePhase 1
Planned participants18
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase Ib study evaluating PMD-026, an oral inhibitor of ribosomal protein S6 kinase A1 (RSK1), in participants with myelofibrosis (MF).The dose escalation portion utilizes a standard 3+3 design to evaluate two dose levels with an additional dose de-escalation portion to identify the recommended phase II dose (RP2D); subsequently, an additional 6 patients will be enrolled in the dose expansion portion evaluating the efficacy of PMD-026.

This description comes directly from the study's public registry record.

Talk to the study team

Amy W Zhou, M.D.  ·  314-362-8814  ·  a.zhou@wustl.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Washington University School of MedicineSt Louis, Missouri, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07379125