Condition: Breast Cancer · HER2/CEP17 Ratio · Sponsor: Shandong Cancer Hospital and Institute
Previous studies suggest that among patients receiving trastuzumab monotherapy, a HER2/CEP17 ratio \>7.0 (ultra-high expression) is associated with poorer disease-free survival (DFS). Dual-target therapy (trastuzumab + pertuzumab) has become the standard treatment for high-risk HER2-positive breast cancer; however, whether it can predict outcomes in patients with ultra-high HER2 expression remains unsupported by clinical data. To analyze the clinicopathological characteristics and prognostic relationship between the HER2 ultra-high expression group and the normal expression group in non-metastatic HER2-positive breast cancer patients who received dual-target therapy.
This description comes directly from the study's public registry record.
Fangchao Zheng, MD · 86-67627005 · sgzhfch@yeah.net
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| Department of Medical Oncology | Jinan, Shandong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07376174