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Study identifier: NCT07374029 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Adoptive T Cell Therapy With DC/AML Fusion Vaccine Plus Decitabine and Venetoclax in AML

Condition: Acute Myeloid Leukemia · Acute Myeloid Leukemia, in Relapse  ·  Sponsor: David Avigan

PhasePhase 1
Planned participants30
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The goal of this research study is to test if the combination of a new T cell therapy (dendritic cell (DC) / acute myeloid leukemia (AML) primed T cells), vaccine (DC/AML fusion vaccine) and standard of care decitabine and venetoclax is feasible and safe and effective for treatment of acute myeloid leukemia (AML). The names of the study drugs involved in this study are: * DC/AML fusion vaccine (immune cell vaccine) * Granulocyte-macrophage colony-stimulating factor (GM-CSF) (a type of growth factor or hormone) * DC/AML Primed T cells (immune cells) * Decitabine (a type of chemotherapy drug) * Venetoclax (a type of antineoplastic agent)

This description comes directly from the study's public registry record.

Talk to the study team

David Avigan, MD  ·  617-667-9920  ·  davigan@bidmc.harvard.edu

Emma Logan, MSN  ·  617-667-9920  ·  eklogan@bidmc.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07374029