Condition: Amyotrophic Lateral Sclerosis (ALS) · Sponsor: Nura Bio
The purpose of this trial is to learn about the effects of NB-4746 compared with placebo in people with amyotrophic lateral sclerosis. The questions this trial aims to answer in comparing NB-4746 to placebo are: * What adverse events associated with taking NB-4746 are reported during this trial? (An adverse event is any sign or symptom that participants have during a trial. Adverse events may or may not be caused by treatments in the trial.) * How does NB-4746 move into, through, and out of the body of the participants? * What is the change in the level of neurofilament light (NfL) in the participants' blood? (NfL is a marker used to measure the extent of damage to the nerve cells.) This trial has 2 parts. The trial doctors will start Part A before starting Part B of the trial. Participants have an option to enter the open label extension after completing Part A or Part B. Part A: Participants will be randomly placed into 1 of the 3 groups. There are equal chances to be assigned to either group. Group 1: Participants will receive NB-4746 capsules at a low dose to take by mouth twice daily for 1 month. Group 2: Participants will receive NB-4746 capsules at a high dose to take by mouth twice daily for 1 month. Group 3: Participants will receive placebo capsules to take twice daily for approximately 1 month. Part B: Participants will be randomly placed into 1 of the 2 groups. There are equal chances to be assigned to either group. Group 1: Participants will receive NB-4746 …
This description comes directly from the study's public registry record.
Lahar Mehta, MD · 801-918-7637 · lmehta@nurabio.com
Always discuss trial participation with your own doctor first.
| Concord Repatriation General Hospital | Concord, New South Wales, Australia | Recruiting |
| Neuroscience Research Australia | Randwick, New South Wales, Australia | Recruiting |
| Royal Brisbane and Women's Hospital | Brisbane, Queensland, Australia | Recruiting |
| Flinders Medical Centre | Bedford Park, South Australia, Australia | Recruiting |
| Calvery Health care Bethlehem | Caulfield South, Victoria, Australia | Recruiting |
| Perron Institute | Nedlands, Western Australia, Australia | Recruiting |
| Stan Cassidy Center for Rehabilitation | Fredericton, New Brunswick, Canada | Recruiting |
| Genge Partners | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07369076